Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.
Identifieur interne : 003989 ( Main/Exploration ); précédent : 003988; suivant : 003990Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.
Auteurs : A. Kittaka [Japon] ; T. Kuze ; T. Asakura ; K. Ito ; T. Miyasaka ; J. InoueSource :
- Bioorganic & medicinal chemistry letters [ 0960-894X ] ; 1998.
Descripteurs français
- KwdFr :
- MESH :
- analogues et dérivés : Uridine.
- métabolisme : ADN, Facteur de transcription NF-kappa B, Oligonucléotides, Uridine.
- Dimérisation.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : Uridine.
- chemical , metabolism : DNA, NF-kappa B, Oligonucleotides, Uridine.
- Dimerization.
Abstract
5-Formyl-2'-O-methyluridine was incorporated into the various positions of oligonucleotide 26-mers containing the NF-kappa B binding sequence. Some of them showed binding selectivity toward the homo- and heterodimers of subunits of NF-kappa B.
DOI: 10.1016/s0960-894x(98)00584-8
PubMed: 9873704
Affiliations:
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Le document en format XML
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